abstract：:The G2A receptor was originally identified by virtue of its transcriptional induction in murine B lymphoid cells in response to oncogenic transformation and treatment with various DNA-damaging agents. While preliminary characterization of cellular responses to G2A overexpression in fibroblastic cell lines suggested th...

journal_title：Prostaglandins & other lipid mediators

authors： Kabarowski JH

更新日期：2009-09-01 00:00:00

abstract：:Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a bioactive phospholipid with mitogenic and/or morphological effects on many cell types. In addition, LPA has been reported to play important roles in various biological processes. It was originally thought that the cellular effects of LPA are mediate...

journal_title：Prostaglandins & other lipid mediators

authors： Ishii S,Noguchi K,Yanagida K

更新日期：2009-09-01 00:00:00

abstract：AIM:This study investigates the effects of montelukast sodium (MK) (CysLTLT1 receptor antagonist) on CCl(4)induced hepatopathy on rat. MATERIAL AND METHODS:We worked on 4 groups of 10 Wistar male rats each. The groups received as follows: group I (control group) - saline, group II - MK 5mg/kg/day i.p. for 5 days, grou...

journal_title：Prostaglandins & other lipid mediators

authors： Cuciureanu M,Căruntu ID,Păduraru O,Stoica B,Jerca L,Crauciuc E,Nechifor M

更新日期：2009-04-01 00:00:00

abstract：:Macrophages express P2X(7) and other nucleotide (P2) receptors, and display the phenomena of extracellular ATP (ATP(e))-induced P2X(7)-dependent membrane permeabilization and cell death by apoptosis and necrosis. P2X(7) receptors also cooperate with toll-like receptors (TLRs) to induce inflammasome activation and IL-1...

journal_title：Prostaglandins & other lipid mediators

authors： Costa-Junior HM,Mendes AN,Davis GH,da Cruz CM,Ventura AL,Serezani CH,Faccioli LH,Nomizo A,Freire-de-Lima CG,Bisaggio Rda C,Persechini PM

更新日期：2009-01-01 00:00:00

abstract：:Plasma activity of the platelet-activating factor acetylhydrolase (PAF-AH) plays an important role in inflammation and atherosclerotic process in chronic diseases. We aimed to evaluate the levels of PAF-AH activity and their association with the metabolic profile and chronic complications in patients with type 1 diabe...

journal_title：Prostaglandins & other lipid mediators

authors： Gomes MB,Cobas RA,Nunes E,Nery M,Castro-Faria-Neto HC,Tibiriçá E

更新日期：2008-12-01 00:00:00

abstract：:Ultraviolet light radiation (UVR) has profound effects upon human skin. Yet, the exact targets for UVR are unclear. Inasmuch as UVR is a known pro-oxidative stressor, one potential target for UVR could be oxidatively modified glycerophosphocholines (GPC). Importantly, recent studies demonstrate that these oxidized GPC...

journal_title：Prostaglandins & other lipid mediators

authors： Konger RL,Marathe GK,Yao Y,Zhang Q,Travers JB

更新日期：2008-12-01 00:00:00

abstract：:Inflammation triggers an increase in osteoclast (bone resorbing cell) number and activity. Osteoclastogenesis is largely controlled by a triad of proteins consisting of a receptor (RANK), a ligand (RANK-L) and a decoy receptor (osteoprotegerin, OPG). Whilst RANK is expressed by osteoclasts, RANK-L and OPG are expresse...

journal_title：Prostaglandins & other lipid mediators

authors： Poulsen RC,Wolber FM,Moughan PJ,Kruger MC

更新日期：2008-02-01 00:00:00

abstract：:The primary prostaglandins PGE(2) and PGF(2 alpha) are metabolized in tissues by a series of enzymatic and non-enzymatic reactions. To measure metabolic rates and individual reaction rates it is necessary to extract the parent prostaglandins and metabolites before the separation and quantification of each compound is ...

journal_title：Prostaglandins & other lipid mediators

authors： Welsh TN,Hubbard S,Mitchell CM,Mesiano S,Zarzycki PK,Zakar T

更新日期：2007-06-01 00:00:00

abstract：:Leukotriene B4 acts through its receptors, BLT(1) and BLT(2), however, their expression in rheumatoid arthritis is unknown. In this experiment, BLT(1) and BLT(2) mRNA expressions in the synovium of rats with collagen-induced arthritis (CIA) at days 1, 3, 7 and 14 after CIA onset were analyzed by RT-PCR. The expression...

journal_title：Prostaglandins & other lipid mediators

authors： Han C,Huang H,Hu M,Wang Q,Gao Y,Liu Y

更新日期：2007-05-01 00:00:00

abstract：:To investigate the mechanisms of the release of lyso platelet-activating factor (PAF), an alkyl ether-linked lysophosphatidylcholine, from the kidney epithelial cell line LLC-PK1, the cell monolayer was incubated with a fluorescence-labeled lysoPAF analog, Bodipy-lysoPAF, on either the basolateral or apical side. The ...

journal_title：Prostaglandins & other lipid mediators

authors： Tsutsumi T,Morishige J,Fukuzawa K,Tokumura A

更新日期：2007-02-01 00:00:00

abstract：:Arachidonic acid (AA) and its metabolites mediate many physiological processes including reproduction and endocrinology. The current study investigated effects of several inhibitors of AA cascade on steroidogenesis by rat corpus luteum cells in vitro. Dispersed luteal cells prepared from rat corpus luteum on day 6 of ...

journal_title：Prostaglandins & other lipid mediators

authors： Kurusu S,Ohkawa M,Kawaminami M

更新日期：2007-02-01 00:00:00

abstract：:The reactivity and Ca2+ sensitivity of fresh as well as organ-cultured guinea pig bronchi challenged with 5-oxo-ETE and 14,15-EET were compared. Tension measurements, performed on fresh and 3-day cultured bronchi, revealed that the contractile responses to 5-oxo-ETE were largely increased in cultured explants, while 1...

journal_title：Prostaglandins & other lipid mediators

authors： Morin C,Rousseau E

更新日期：2007-01-01 00:00:00

abstract：:12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination wi...

journal_title：Prostaglandins & other lipid mediators

authors： Fürstenberger G,Epp N,Eckl KM,Hennies HC,Jørgensen C,Hallenborg P,Kristiansen K,Krieg P

更新日期：2007-01-01 00:00:00

abstract：:Cytosolic phospholipase A(2)-alpha (cPLA(2)) plays an important role in the release of arachidonic acid and in cell injury. Activation of cPLA(2) is dependent on a rise in cytosolic Ca(2+) concentration, membrane association via the Ca(2+)-dependent lipid binding (CaLB) domain, and phosphorylation. This study addresse...

journal_title：Prostaglandins & other lipid mediators

authors： Le Berre L,Takano T,Papillon J,Lemay S,Cybulsky AV

更新日期：2006-12-01 00:00:00

abstract：UNLABELLED:Our past studies have shown that porcine myometrium produce prostaglandins (PG) during luteolysis and early pregnancy and that oxytocin (OT) and its receptor (OTr) support myometrial secretion of prostaglandins E2 and F2alpha (PGE2 and PGF2alpha) during luteolysis. This study investigates the role of intrace...

journal_title：Prostaglandins & other lipid mediators

authors： Franczak A,Kurowicka B,Oponowicz A,Petroff BK,Kotwica G

更新日期：2006-10-01 00:00:00

abstract：:We investigated the regulation of cyclooxygenase-2 (COX-2) by 17-beta-estradiol (E2) in the rat oviduct. We observed that COX-2 is expressed mainly in proestrous and estrous stages, periods under estrogenic influence. While exogenous administration of E2 (1 microg/rat) significantly increased COX-2 protein levels, pro...

journal_title：Prostaglandins & other lipid mediators

authors： Pérez Martínez S,Hermoso M,Farina M,Ribeiro ML,Rapanelli M,Espinosa M,Villalón M,Franchi A

更新日期：2006-09-01 00:00:00

abstract：:Prostaglandin F(2alpha) (PGF(2alpha)) is a major stable prostaglandin formed in vivo in physiological and pathophysiological situations and has mainly potent vasoconstrictive and pro-inflammatory properties. PGF(2alpha) is now used as an indicator of acute and chronic inflammation in human clinical settings but the ex...

journal_title：Prostaglandins & other lipid mediators

authors： Helmersson J,Basu S

更新日期：2006-07-01 00:00:00

abstract：:Under physiological conditions, small amounts of free arachidonic acid (AA) are released from membrane phospholipids, and cyclooxygenase (COX) and acyl-CoA synthetase (ACS) competitively act on this fatty acid to form prostaglandins (PGs) and arachidonoyl-CoA (AA-CoA). In the present study, we investigated the effects...

journal_title：Prostaglandins & other lipid mediators

authors： Sakuma S,Usa K,Fujimoto Y

更新日期：2006-05-01 00:00:00

abstract：AIMS:To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A2 synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs. METHODS:Twelve animals were randomly divided in two groups: a control group ...

journal_title：Prostaglandins & other lipid mediators

authors： Kolh P,Rolin S,Tchana-Sato V,Pétein M,Ghuysen A,Lambermont B,Hanson J,Magis D,Segers P,Masereel B,D'Orio V,Dogne JM

更新日期：2006-03-01 00:00:00

abstract：:The isolation of two new classes of human docosahexaenoic acid oxidation products, the neuroprostanes and the neurofurans, have been reported. Facile nomenclature systems that will allow the rational differentiation of each of the isomeric structures comprising the families of NeuroP's and NeuroF's, represented, respe...

journal_title：Prostaglandins & other lipid mediators

authors： Taber DF,Jackson Roberts L 2nd

更新日期：2005-12-01 00:00:00

abstract：:Prostaglandin E1 is used to reopen the constricted ductus arteriosus in neonates with ductus-dependent circulation. To clarify possible prostanoid receptor agonists that can reopen the neonatal ductus with fewer side effects, we studied in vivo reopening of the neonatal ductus arteriosus by AE1-329, a prostanoid EP4-r...

journal_title：Prostaglandins & other lipid mediators

authors： Momma K,Toyoshima K,Takeuchi D,Imamura S,Nakanishi T

更新日期：2005-12-01 00:00:00

abstract：:Sphingolipids (SLs) have a biomodulatory role in physiological as well as pathological cardiovascular conditions. This study aims to assess the variation of SL mediators and metabolizing enzymes in the growing and hypoxic rat heart. Sprague-Dawley rats were placed in a hypoxic environment at birth. Control animals rem...

journal_title：Prostaglandins & other lipid mediators

authors： El Alwani M,Usta J,Nemer G,El Sabban M,Nasser M,Bitar H,Souki R,Dbaibo GS,Bitar FF

更新日期：2005-12-01 00:00:00

abstract：:This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) ent...

journal_title：Prostaglandins & other lipid mediators

authors： Chun J

更新日期：2005-09-01 00:00:00

abstract：:Lipids are central to the regulation and control of several cellular functions. They form many of the important structural features of cells, and are critical members of cellular signal transduction pathways. Cellular dysfunction is often caused by errors in lipid signaling; therefore, the proteins that interact with,...

journal_title：Prostaglandins & other lipid mediators

authors： Feng L

更新日期：2005-09-01 00:00:00

abstract：:Platelet-activating factor (PAF) and its receptors are involved in inflammatory-like processes of the uterus associated with increased vascular permeability. PAF is supposed to be influenced by ovarian steroid hormones. The present study was undertaken to examine whether progesterone (P(4)), estradiol (E(2)) or PAF in...

journal_title：Prostaglandins & other lipid mediators

authors： Tiemann U,Bücher K,Pfarrer Ch,Pöhland R,Becker F,Kanitz W,Schmidt P

更新日期：2005-05-01 00:00:00

abstract：:In contrast to conventionally used immunoassays, thin layer chromatography (TLC)--by prelabeling of cells with radioactive arachidonic acid (AA)--allows to differentiate between cellularly built and added prostanoids and thus to investigate feedback effects of prostanoids on their own release. PGD2, TXB2 and PGE2 rele...

journal_title：Prostaglandins & other lipid mediators

authors： Pestel S,Jungermann K,Schieferdecker HL

更新日期：2005-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) induces a release of tumor necrosis factor (TNF)-alpha, endothelin (ET)-1, interleukin (IL)-1alpha, IL-6 and IL-10 in rat liver macrophages (Kupffer cells). Prostaglandin (PG)E2 inhibits the release of the fibrogenic mediators TNF-alpha, ET-1 and IL-1alpha, and enhances the release of the anti...

journal_title：Prostaglandins & other lipid mediators

authors： Treffkorn L,Scheibe R,Maruyama T,Dieter P

更新日期：2004-10-01 00:00:00

abstract：:Recent advancements in mass spectrometry, especially the development of electrospray tandem mass spectrometry (ESI/LC/MS2) and matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI/TOF), have greatly facilitated analysis of complex biomolecules. It has now become possible to profile, in relatively s...

journal_title：Prostaglandins & other lipid mediators

authors： Balazy M

更新日期：2004-04-01 00:00:00

abstract：:Recently, the isolation of a new class of human arachidonic acid oxidation products, the isofurans, was reported. These are produced in vivo by a free radical mechanism independent of the cyclooxygenase enzymes. Because these compounds are tetrahydrofuran derivatives that are related biosynthetically to the isoprostan...

journal_title：Prostaglandins & other lipid mediators

authors： Taber DF,Fessel JP,Roberts LJ 2nd

更新日期：2004-01-01 00:00:00

abstract：:The essential fatty acid deficiency (EFAD) is a metabolic condition related to cancer development. We studied the effect of eicosapentaenoic acid (EPA, 20:5 n-3) and eicosatrienoic acid (ETA, 20:3 n-9), an essential fatty acid (EFA) and non-EFA respectively, on tumour cells parameters linked to tumour progression and ...

journal_title：Prostaglandins & other lipid mediators

authors： Heyd VL,Eynard AR

更新日期：2003-07-01 00:00:00

abstract：:Lipid mediators can exert their effects by interactions with well-characterised cell surface G-protein-linked receptors. Recently, a group of intracellular receptors have been identified that are activated by a large variety of lipid-derived mediators. Amongst these novel targets, the peroxisome proliferator-activated...

journal_title：Prostaglandins & other lipid mediators

authors： Bishop-Bailey D,Wray J

更新日期：2003-04-01 00:00:00

abstract：:GRKs play a key role in regulating G protein-coupled receptor (GPCR) responsiveness. To investigate the role of GRKs in desensitization of TP, we replaced threonines with favorable phosphorylation motifs for GRKs (positions 226 and 230) with alanine. Mutant and wild-type receptors were expressed in cell culture models...

journal_title：Prostaglandins & other lipid mediators

authors： Flannery PJ,Spurney RF

更新日期：2002-09-01 00:00:00

abstract：:Interest in the possible involvement of the platelet-activating factor (PAF) in tumor growth and invasiveness has been stimulated by the recognition that PAF influences various biological responses relevant to metastatic diffusion, such as angiogenesis, adhesiveness to endothelia and cellular motility. In the present ...

journal_title：Prostaglandins & other lipid mediators

authors： Fallani A,Grieco B,Barletta E,Mugnai G,Giorgi G,Salvini L,Ruggieri S

更新日期：2002-09-01 00:00:00

abstract：:The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family that includes the mannose receptor. PLA2R regulates a variety of biological responses elicited by specific types of secretory PLA2s (sPLA2s). Group IB sPLA2 (sPLA2-IB) acts as an endogenous PLA2R lig...

journal_title：Prostaglandins & other lipid mediators

authors： Hanasaki K,Arita H

更新日期：2002-08-01 00:00:00

abstract：:In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylat...

journal_title：Prostaglandins & other lipid mediators

authors： Rådmark O

更新日期：2002-08-01 00:00:00

abstract：:Prostaglandin (PG) D2 is a major PG produced in the central nervous system and is involved in the regulation of sleep and pain responses through DP receptors. It is also actively produced by mast cells, basophils, and Th2 cells, acting as an allergic mediator through DP and CRTH2 receptors. PGD2 is further dehydrated ...

journal_title：Prostaglandins & other lipid mediators

authors： Urade Y,Eguchi N

更新日期：2002-08-01 00:00:00

abstract：:Leukotriene C4 synthase (LTC4S) conjugates LTA4 with glutathione (GSH) to form LTC4, the parent compound of the cysteinyl LTs. LTC4S is an 18 kDa membrane protein and functions as a noncovalent homodimer. The enzyme activity of LTC4S is augmented by Mg2+ and inhibited by Co2+ and the function of 5-lipoxygenase (LO) ac...

journal_title：Prostaglandins & other lipid mediators

authors： Lam BK,Austen KF

更新日期：2002-08-01 00:00:00

abstract：:Cyclooxygenase (COX) is the key enzyme for prostaglandin (PG) synthesis. PGs are mediators of many critical physiological and inflammatory responses. There are two isoforms, COX-1 and COX-2, both of which are constitutively expressed in the central nervous system (CNS). Studies have shown that COX-1 and COX-2 are invo...

journal_title：Prostaglandins & other lipid mediators

authors： Chen N,Restivo A,Reiss CS

更新日期：2002-02-01 00:00:00

abstract：:Apoptosis at the site of rupture has been proposed to play a role in premature rupture of the fetal membranes, a condition associated with increased risk of neonatal sepsis and preterm birth. We investigated the ability of peroxisome proliferator-activated receptor (PPAR)-gamma ligands 15-deoxy-delta12,14PGJ2 (15d-PGJ...

journal_title：Prostaglandins & other lipid mediators

authors： Keelan J,Helliwell R,Nijmeijer B,Berry E,Sato T,Marvin K,Mitchell M,Gilmour R

更新日期：2001-12-01 00:00:00

abstract：:We have demonstrated that the baboon placenta expressed the mRNAs and proteins for secretory and cytosolic phospholipase A2 (PLA2) enzymes and that cPLA2 expression increased with advancing gestation in association with the increase in placental estrogen production. To determine whether estrogen regulates placental PL...

journal_title：Prostaglandins & other lipid mediators

authors： Rosenthal MD,Albrecht ED,Pepe GJ

更新日期：2001-10-01 00:00:00